Contributions of the anterior cingulate cortex and amygdala to pain- and fear-conditioned place avoidance in rats

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• 作者：Gao ; Yong-Jing ; Ren ; Wen-Hua ; Zhang ; Yu-Qiu ; Zhao ; Zhi-Qi
• 关键词：Anterior cingulate cortex ; Amygdala ; Conditioned place avoidance ; Nociceptive behavior ; Pain ; Fear
• 刊名：Pain
• 出版年：2004
• 出版时间：July, 2004
• 年：2004
• 卷：110
• 期：1-2
• 页码：343-353
• 全文大小：380 K

文摘

The pain experience includes a sensory-discriminative and an affective-emotional component. The sensory component of pain has been extensively studied, while data about the negative affective component of pain are quite limited. The anterior cingulate cortex (ACC), and amygdala are thought to be key neural substrates underlying emotional responses. Using formalin-induced conditioned place avoidance (F-CPA) and electric foot-shock conditioned place avoidance (S-CPA) models, the present study observed the effects of bilateral excitotoxic (quinolinic acid 200nmol/μl) lesions of the ACC and amygdala on pain and fear induced negative emotion, as well as on sensory component of pain. In the place-conditioning paradigm, both intraplantar (i.pl.) injection of formalin and electric foot-shock produced conditioned place avoidance. Excitotoxin-induced lesion of either the ACC or amygdala significantly reduced the magnitude of F-CPA. However, the decrease in the magnitude of S-CPA occurred only in the amygdala, but not ACC lesioned animals. Neither ACC nor amygdala lesion significantly changed formalin-induced acute nociceptive behaviors. These results suggest that the amygdala is involved in both pain- and fear-related negative emotion, and the ACC might play a critical role in the expression of pain-related negative emotion.