GABAergic disinhibition facilitates polysynaptic excitatory transmission in rat anterior cingulate cortex
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- 作者：Hua Wang ; Wen-Hua Ren ; Yu-Qiu Zhang and Zhi-Qi Zhao
- 关键词：GABAA receptor ; Polysynaptic response ; Conditioned place avoidance ; Anterior cingulate cortex
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2005
- 出版时间：23 December 2005
- 年：2005
- 卷：338
- 期：3
- 页码：1634-1639
- 全文大小：246 K
文摘
Various studies implicate the anterior cingulate cortex (ACC) in processing pain. Combining whole-cell patch clamp recordings in rat ACC slices and a formalin-induced conditioned place avoidance (F-CPA) behavioral model, the present study was to address the effect of GABAA receptors on excitatory transmission to ACC layer V neurons and its possible functional significance related to pain. Removal of GABAA inhibition by bicuculline (10 μM) induced a novel long-lasting response in layer V neurons, which could be blocked by high divalent extracellular solution and was sensitive to relatively higher rate stimuli. Co-application of NMDA receptor antagonist APV (50 μM) and non-NMDA receptor antagonist DNQX (10 μM) completely blocked the responses. Enhancement of inhibition by intra-ACC microinjection of muscimol abolished the acquisition of F-CPA without affecting formalin-induced acute nociceptive responses. These results suggest that GABAA inhibition may be involved in pain-related aversion by modulating glutamate-mediated excitatory transmission in the ACC.