Inhibition of mammalian target of rapamycin activation in the rostral anterior cingulate cortex attenuates pain-related aversion in rats
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- 作者：Bo Lua ; Jingyan Jiangb ; Jianliang Sunc ; Chun Xiaoc ; Bo Menga ; Jinwei Zhenga ; Xiaoyu Lia ; Ruichun Wanga ; Guorong Wua ; Junping Chena ; 13858222873@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：mTOR ; mammalian target of rapamycin ; p70S6k ; p70 ribosomal S6 protein kinase ; ACC ; anterior cingulate cortex ; rACC ; rostral anterior cingulate cortex ; F-CPA ; formalin-induced conditioned place avoidance ; CPP ; conditioned place preference ; AMPA ; a-amino-3-hydroxy-5-methyl-isoxozole propionic acid ; KA ; kainite
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：310
- 期：Complete
- 页码：51-58
- 全文大小：1554 K
文摘
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A nociceptive stimulus induced an upregulation of p-mTOR and p-p70S6K in the rACC.
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Intra-rACC injection of rapamycin attenuated pain-related aversion.
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Rapamycin infusion into the rAAC did not affect nociceptive behaviors.