Neurobiology of fibromyalgia and chronic widespread pain
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- 作者：Kathleen A. Slukaa ; kathleen-sluka@uiowa.edu" class="auth_mail" title="E-mail the corresponding author ; Daniel J. Clauwb
- 关键词：ASICs ; acid sensing ion channels ; CGRP ; calcitonin-gene-related peptide ; CPM ; conditioned pain modulation ; DNIC ; diffuse noxious inhibitory control ; fMRI ; functional magnetic resonance imaging ; HPA ; hypothalamic pituitary adrenal ; IBS ; irritable bowel syndrome ; NGF ; nerve growth factor ; PBMCs ; peripheral blood mononuclear cells ; QST ; quantitative sensory testing
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：3 December 2016
- 年：2016
- 卷：338
- 期：Complete
- 页码：114-129
- 全文大小：1285 K
文摘
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Fibromyalgia is associated with altered processing in the CNS with enhanced excitability and decreased inhibition.
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Animal models mimicking fibromyalgia have discovered changes in the CNS from the spinal cord to the cortex.
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Evidence that supports altered CNS processing in human subjects, and the translational data in animal models on mechanisms.