Acquisition of CS-US contingencies during Pavlovian fear conditioning and extinction in social anxiety disorder and posttraumatic stress disorder
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- 作者：Christine A. Rabinaka ; b ; c ; d ; e ; rabinak@wayne.edu" class="auth_mail" title="E-mail the corresponding author ; Shoko Morie ; f ; Maryssa Lyonse ; Mohammed R. Miladg ; K. Luan Phane ; h ; i ; j
- 关键词：Social phobia ; PTSD ; Aversive ; Classical conditioning ; Threat expectancy
- 刊名：Journal of Affective Disorders
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：207
- 期：Complete
- 页码：76-85
- 全文大小：614 K
文摘
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SAD and PTSD generalize expectations of an aversive US across CSs, even when a CS never signals an aversive US.
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PTSD tended to overestimate that an aversive US would occur in general.
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SAD and PTSD showed impaired extinction learning of a CS-US association.
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SAD and PTSD could not differentiate between a threat and safe cue during extinction learning.
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Fear learning and extinction abnormalities may be transdiagnostic mechanism of fear-based disorders.