Effects of the metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on rats tested with the paired associates learning task in touchscreen-equipped operant conditioning chambers
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- 作者：Brittney R. Lins ; John G. Howland ; john.howland@usask.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cognition ; Operant conditioning ; NMDA receptor ; MK-801 ; Glutamate ; Schizophrenia
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：301
- 期：Complete
- 页码：152-160
- 全文大小：2012 K
文摘
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Acute MK-801 treatment impairs paired associates learning, a visual-spatial memory task.
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mGluR5 positive allosteric modulator CDPPB has no consistent effects on PAL in well-trained rats.
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CDPPB was ineffective at reversing the MK-801 induced impairments in PAL.