Radioimmunotherapy-based conditioning for hematopoietic stem cell transplantation: Another step forward

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• 作者：Alaa M. Ali^a ; ^{alaaali@wustl.edu" class="auth_mail" title="E-mail the corresponding author} ; Farrokh Dehdashti^b ; ¹ ; ^{dehdashtif@wustl.edu" class="auth_mail" title="E-mail the corresponding author} ; John F. DiPersio^a ; ² ; ^{jdipersi@wustl.edu" class="auth_mail" title="E-mail the corresponding author} ; Amanda F. Cashen^a ; ³ ; ^{acashen@wustl.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Radioimmunotherapy ; Hematopoietic stem cell transplantation ; Beta emitters ; Alpha emitters ; Pre-targeting ; Acute myeloid leukemia ; Lymphoma ; Multiple myeloma
• 刊名：Blood Reviews
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：30
• 期：5
• 页码：389-399
• 全文大小：4139 K

文摘

Radioimmunotherapy is increasingly used alone and in combination with standard chemotherapy as a preparative conditioning tool for patients with variety of hematological malignancies before allogeneic and autologous stem cell transplantation. This approach, if optimized, has the potential to close the gap between the benefit and toxicity of conditioning regimens. This article is intended to provide a summary of the basic elements of this approach as well as a concise and up-to-date scoping review of the studies that evaluated the safety and efficacy of integrating radioimmunotherapy in the conditioning regimens.