Effects of amyloid 尾-peptide fragment 31-35 on the BK channel-mediated K+ current and intracellular free Ca2+ concentration of hippocampal CA1 neurons
详细信息 查看全文
- 作者：Yu Zhanga ; zhyucnm@gmail.com" class="auth_mail ; zhyucnm@163.com" class="auth_mail ; Zhi-Gang Shia ; Zhi-Hua Wangb ; Jian-Guo Lia ; Jin-Yuan Chenc ; Ce Zhanga ; cezh2002@yahoo.com" class="auth_mail
- 关键词：A尾31&ndash ; 35 ; Ca2+-activated big K+ currents (BK currents) ; Whole-cell patch recording ; Ca2+ imaging ; Hippocampal CAl neurons ; Rats
- 刊名：Neuroscience Letters
- 出版年：7 May 2014
- 年：2014
- 卷：568
- 期：Complete
- 页码：72-76
- 全文大小：1030 K
文摘
- •
The early-transient currents are from large conductance Ca2+-activated K+ channels.
- •
A尾31–35 is the shortest active fragment of full A尾 sequence.
- •
A尾31–35 could suppress the early-transient part of BK currents.
- •
A尾31–35 elevated the intracellular load of Ca2+, as is the larger fragment A尾25–35.