Dynamic conformational ensembles regulate casein kinase-1 isoforms: Insights from molecular dynamics and molecular docking studies
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- 作者：Surya Pratap Singha ; suryabioinfo@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Dwijendra K. Guptab ; 1
- 关键词：Wnt signaling pathway ; Molecular dynamics simulation ; Principal component analysis
- 刊名：Computational Biology and Chemistry
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：61
- 期：Complete
- 页码：39-46
- 全文大小：2888 K
文摘
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A comparative MD simulation of two isoforms of CK1 reveals their synchronized behavior.
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The two state conformational mechanism for CK1-isoforms is proposed.
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Docking studies at different conformations validates the conformational switch.