Conserved stem fragment from H3 influenza hemagglutinin elicits cross-clade neutralizing antibodies through stalk-targeted blocking of conformational change during membrane fusion
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- 作者：Xin Gonga ; He Yina ; Yuhua Shia ; Shanshan Guana ; Xiaoqiu Hea ; Lan Yanga ; Yongjiao Yua ; Ziyu Kuaia ; Chunlai Jianga ; b ; Wei Konga ; b ; Song Wangc ; Yaming Shana ; b ; shanym@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Influenza virus ; Hemagglutinin stem ; Neutralizing activities ; Conformational change ; Membrane fusion
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：172
- 期：Complete
- 页码：11-20
- 全文大小：2672 K
文摘
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Located at the turning point of hemagglutinin2 (HA2) conformational change during membrane fusion of influenza virus, a conserved stem fragment with both B- and T-cell epitopes was identified.
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The immunization of conserved stem fragment could induce strong humoral immune response and cross-clade neutralizing antisera against strains from H3 subtype in group 2.
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The cross-clade neutralizing antisera possessed neutralizing activities potentially by blocking conformational change at the turning point of HA stem where exposed for limit periods of time during membrane fusion.