Facile synthesis of novel halogenated 4-pyrazolylspirocyclic-β-lactams: versatile heterocyclic synthons
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- 作者：Aman Bhallaa ; amanbhalla@pu.ac.in" class="auth_mail" title="E-mail the corresponding author ; Shamsher S. Baria ; Jitender Bhallaa ; Sadhika Khullarb ; Sanjay Mandalb
- 关键词：β-Lactams ; Spirocyclic ; Halogenated ; Rotamers ; X-ray crystal structures
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：22 June 2016
- 年：2016
- 卷：57
- 期：25
- 页码：2822-2828
- 全文大小：1520 K
文摘
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Exploration of cyclisation, electrophilic addition and electophilic substituttion in mild synthesis.
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Facile synthesis of halogenated 4-pyrazolylspirocyclic-β-lactams via halogen mediated intrasulfenyl cyclisation.
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Comparative studies with halogenating agents for attaining stereoselectivity and variety.
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Stereochemistry at C3 of 3-propargyloxy-β-lactams 3a was established by X-ray structural analysis.
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4-Pyrazolylspirocyclic-β-lactams 6a & 7a were established by X-ray crystallographic studies.
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NMR experiments were performed to confirm conformational isomerism shown by 4-pyrazolyl-β-lactams.