Homogentisic acid induces aggregation and fibrillation of amyloidogenic proteins

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• 作者：Daniela Braconi^a ; ¹ ; Lia Millucci^a ; ¹ ; Andrea Bernini^a ; Ottavia Spiga^a ; Pietro Lupetti^b ; Barbara Marzocchi^a ; Neri Niccolai^a ; Giulia Bernardini^a ; ¹ ; Annalisa Santucci^a ; ^{annalisa.santucci@unisi.it}
• 关键词：AKU ; alkaptonuria ; AA ; amyloid-A ; ANP ; atrial natriuretic peptide ; BQA ; benzoquinone acetate ; CR ; Congo Red ; HMW ; high molecular weight ; HGD ; homogentisate 1.2-dioxygenase ; HGA ; homogentisic acid ; NBT ; nitro blue tetrazolium ; SAA ; Serum Amyloid A ; TEM ; transmission electron microscopy ; Ttr ; transthyretin ; WB ; Western blot ; α-Syn ; α-synuclein
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1861
• 期：2
• 页码：135-146
• 全文大小：2149 K
• 卷排序：1861

文摘

HGA promotes the aggregation kinetics of amyloidogenic peptides/proteins. HGA enhances the aggregation into different amyloid structures. BQA, originated from oxidation of HGA, can bind to SAA and α-Syn. LC/MS and in silico analyses indicate possible binding sites for HGA and BQA in SAA.