Sustained release of aspirin and vitamin C from titanium nanotubes: An experimental and stimulation study
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- 作者：Weihu Yang ; yangweihu@cqu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Conghui Deng ; Peng Liu ; Yan Hu ; Zhong Luo ; Kaiyong Cai ; kaiyong_cai@cqu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Titanium nanotubes ; Drug release ; Small molecule drugs ; Polylactic acid ; Molecular dynamics simulation
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：64
- 期：Complete
- 页码：139-147
- 全文大小：3266 K
文摘
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Nanotubes on titanium implants were used as nano-reservoirs for small molecular drugs.
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Low molecular weight polylactic acid was loaded as encapsulating material to retard the burst release of drugs.
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Molecular dynamics simulation was performed to simulate the release process.
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Dissipative particle dynamics simulation was carried to interpret the interaction mechanism.