Design, synthesis and evaluation of 6-aryl-indenoisoquinolone derivatives dual targeting ERα and VEGFR-2 as anti-breast cancer agents
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- 作者：Zhichao Tanga ; b ; Chengzhe Wua ; b ; Tianlin Wanga ; b ; Kejing Laoa ; b ; Yejun Wanga ; b ; Linyi Liua ; b ; Moses Muyabaa ; b ; Pei Xua ; b ; Conghui Hea ; b ; Guoshun Luoa ; b ; Zhouyang Qiana ; b ; Shaoxiong Niua ; b ; Lijun Wangc ; Ying Wangc ; Hong Xiaoc ; Qidong Youa ; b ; Hua Xianga ; b ; xianghua@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Estrogen receptor ; VEGFR-2 ; Dual inhibitor ; Breast cancer
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：8 August 2016
- 年：2016
- 卷：118
- 期：Complete
- 页码：328-339
- 全文大小：1576 K
文摘
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Designed multiple ligands may exert improved efficacy with lower incidence of side effects.
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A series of 6-aryl-indenoisoquinolone derivatives were described as dual ERα and VEGFR-2 inhibitors.
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Compound 21c turned out to be a promising dual targeting candidate for breast cancer.