Genome-wide screening and identification of long noncoding RNAs and their interaction with protein coding RNAs in bladder urothelial cell carcinoma

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• 作者：Longxin Wang^a ; ¹ ; Dian Fu^a ; ¹ ; Yongbin Qiu^b ; ¹ ; Xiaoxiao Xing^c ; Feng Xu^a ; Conghui Han^d ; Xiaofeng Xu^a ; Zhifeng Wei^a ; Zhengyu Zhang^a ; Jingping Ge^a ; Wen Cheng^a ; ^{Dr_chengwen@126.com" class="auth_mail} ; Hai-Long Xie^e ; ^{xhl0078@sina.com.cn" class="auth_mail}
• 关键词：Urothelial carcinoma of bladder ; Long noncoding RNA ; lncRNA ; Co-expression
• 刊名：Cancer Letters
• 出版年：10 July 2014
• 年：2014
• 卷：349
• 期：1
• 页码：77-86
• 全文大小：2269 K

文摘

To understand lncRNAs expression profiling and their potential functions in bladder cancer, we investigated the lncRNA and coding RNA expression on human bladder cancer and normal bladder tissues. Bioinformatic analysis revealed thousands of significantly differentially expressed lncRNAs and coding mRNA in bladder cancer relative to normal bladder tissue. Co-expression analysis revealed that 50% of lncRNAs and coding RNAs expressed in the same direction. A subset of lncRNAs might be involved in mTOR signaling, p53 signaling, cancer pathways. Our study provides a large scale of co-expression between lncRNA and coding RNAs in bladder cancer cells and lays biological basis for further investigation.