Thaulin-1: The first antimicrobial peptide isolated from the skin of a Patagonian frog Pleurodema thaul (Anura: Leptodactylidae: Leiuperinae) with activity against Escherichia coli

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• 作者：Mariela M. Marani^a ; ^{mmarani@cenpat-conicet.gob.ar} ; Luis O. Perez^b ; ^{orlandoperez@cenpat-conicet.gob.ar} ; Alyne Rodrigues de Araujo^c ; ^{alyne.rdearaujo@gmail.com} ; Alexandra Plá ; cido^d ; ^{alexandra.placido@gmail.com} ; Carla F. Sousa^e ; ^{cfilipams@gmail.com} ; Patrick Veras Quelemes^c ; ^{pquelemes@gmail.com} ; Mayara Oliveira^f ; ^{mayaragco@gmail.com} ; Ana G. Gomes-Alves^g ; ^h ; ⁱ ; ^{georgina.alves@ibmc.up.pt} ; Mariana Pueta^j ; ^{mpueta@gmail.com} ; Paula Gameiro^e ; ^{agsantos@fc.up.pt} ; Ana M. Tomá ; s^g ; ^h ; ^k ; ^{atomas@ibmc.up.pt} ; Cristina Delerue-Matos^d ; ^{cmm@isep.ipp.pt} ; Peter Eaton^c ; ^e ; ^{peter.eaton@fc.up.pt} ; Silvia A. Camperi^l ; ^{scamperi@ffyb.uba.ar} ; Né ; stor G. Basso^m ; ^{nbasso@cenpat-conicet.gob.ar} ; Jose Roberto de Souza de Almeida Leite^c ; ^e ; ^f ; ^{jrleite@pq.cnpq.br}
• 刊名：Gene
• 出版年：2017
• 出版时间：20 March 2017
• 年：2017
• 卷：605
• 期：Complete
• 页码：70-80
• 全文大小：1500 K
• 卷排序：605

文摘

Thaulin-1 is the first antimicrobial peptide isolated from the skin of P. thaul. Thaulin-1 is a Gly/Leu-rich peptide with similarities to bombinin peptide family. In organic media, thaulin-1 showed characteristic CD spectra of α–helix structures. Thaulin-1 presents activity against E. coli, K. pneumoniae and S. aureus strains. Thaulin-1 showed low cytotoxicity to mammalian cells.