The C-C chemokine receptor 6 (CCR6) is crucial for Th2-driven allergic conjunctivitis
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- 作者：So-Hyang Chunga ; b ; chungsh@catholic.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Sun Young Changc ; Hyun Jung Leea ; Seong Hyun Choib
- 关键词：Allergic conjunctivitis ; CCR6 ; Eosinophil ; Th2-type immune response
- 刊名：Clinical Immunology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：161
- 期：2
- 页码：110-119
- 全文大小：1434 K
文摘
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Allergic conjunctivitis from an allergen-driven Th2 response is characterized by conjunctival eosinophilic infiltration.
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CCR6 KO mice were significantly protected from EAC and neutralization of CCL20 inhibits the development of EAC.
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Neutralization of CCR6 ligand, CCL20 inhibits the development of experimental allergic conjunctivitis.