Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks
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- 作者：David W. Wyatt1 ; Wanjuan Feng1 ; 2 ; Michael P. Conlin1 ; Matthew J. Yousefzadeh3 ; Steven A. Roberts4 ; Piotr Mieczkowski5 ; Richard D. Wood3 ; Gaorav P. Gupta1 ; 2 ; Dale A. Ramsden1 ; dale_ramsden@med.unc.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：18 August 2016
- 年：2016
- 卷：63
- 期：4
- 页码：662-673
- 全文大小：2948 K
文摘
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Pol θ directs end joining by coupling a microhomology search to synthesis across ends
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Pol θ-mediated end joining is critical when either canonical repair pathway fails
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Pol θ is also essential when cells aberrantly regulate resection of chromosome breaks
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Pol θ-dependent repair can both suppress and promote genome instability