Functional consequences of co-expressing connexin40 or connexin45 with connexin43 on intercellular electrical coupling

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• 作者：Neil M. Thomas^a ; ^{neilmjthomas@gmail.com} ; Rosaire Gray^b ; ^{rosaire.gray@nhs.net} ; Christopher H. Fry^c ; ^{chris.fry@bristol.ac.uk} ; Thomas Desplantez^a ; ¹ ; ^{Thomas.Desplantez@ihu-liryc.fr} ; Nicholas S. Peters^a ; ^{n.peters@imperial.ac.uk} ; Nicholas J. Severs^a ; ^{n.severs@imperial.ac.uk} ; Kenneth T. Macleod^a ; ^{k.t.macleod@imperial.ac.uk} ; Emmanuel Dupont^a ; ^{e.dupont@imperial.ac.uk}
• 关键词：Connexin ; Gap junction ; Heart ; Inducible expression ; Rat liver epithelial cells
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：191-196
• 全文大小：1171 K
• 卷排序：483

文摘

Cx40 and Cx45 are induced as a function of the dose of inducer. Endogenous Cx43 mRNA is reduced by induction of both Cx40 and Cx45. Cx43 protein is reduced by induction of Cx40 but not by induction of Cx45. Electrical coupling of monolayers is unchanged by induction of both Cx40 and Cx45. Cell morphology is altered by induction of Cx45.