- 作者：Colm G. Connolly ; Jing Wu ; Tiffany C. Ho ; Fumiko Hoeft ; Owen Wolkowitz ; Stuart Eisendrath ; Guido Frank ; Robert Hendren ; Jeffrey E. Max ; Martin P. Paulus ; Susan F. Tapert ; Dipavo Banerjee ; Alan N. Simmons ; Tony T. Yang
- 关键词：Adolescent major depression ; amygdala ; default mode network ; insula ; resting-state ; subgenual anterior cingulate
- 刊名：Biological Psychiatry
- 出版年：15 December, 2013
- 年：2013
- 卷：74
- 期：12
- 页码：898-907
- 全文大小：2171 K
Background
Very few studies have been performed to understand the underlying neural substrates of adolescent major depressive disorder (MDD). Studies in depressed adults have demonstrated that the subgenual anterior cingulate cortex (sgACC) plays a pivotal role in depression and have revealed aberrant patterns of resting-state functional connectivity (RSFC). Here, we examine the RSFC of the sgACC in medication-na茂ve first-episode adolescents with MDD.Methods
Twenty-three adolescents with MDD and 36 well-matched control subjects underwent functional magnetic resonance imaging to assess the RSFC of the sgACC.
Results
We observed elevated connectivity between the sgACC and the insula and between the sgACC and the amygdala in the MDD group compared with the control subjects. Decreased connectivity between the sgACC and the precuneus was also found in the MDD group relative to the control subjects. Within the MDD group, higher levels of depression significantly correlated with decreased connectivity between the sgACC and left precuneus. Increased rumination was significantly associated with reduced connectivity between sgACC and the middle and inferior frontal gyri in the MDD group.
Conclusions
Our study is the first to examine sgACC connectivity in medication-na茂ve first-episode adolescents with MDD compared with well-matched control participants. Our results suggest aberrant functional connectivity among the brain networks responsible for salience attribution, executive control, and the resting-state in the MDD group compared with the control participants. Our findings raise the possibility that therapeutic interventions that can restore the functional connectivity among these networks to that typical of healthy adolescents might be a fruitful avenue for future research.