Antihypertensive effects of androgens in conscious, spontaneously hypertensive rats

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• 作者：Mercedes Perusquí ; a^a ; ^{perusqui@unam.mx} ; Nieves Herrera^a ; Mercedes Ferrer^b ; ^c ; John N. Stallone^d ; ^e
• 关键词：SHR ; spontaneously hypertensive rats ; WKY ; Wistar-Kyoto rats ; TES ; testosterone ; 5α-DHT ; 5α-dihydrotestosterone ; 5β-DHT ; 5β-dihydrotestosterone ; BP ; blood pressure ; L-VOCC ; L-type voltage-operated Ca2+ channels ; Tfm ; testicular-feminized male ; AR ; androgen receptor ; SBP ; systolic BP ; DBP ; diastolic BP ; MAP ; mean arterial blood pressure ; HR ; heart rate ; BPM ; beats per minute ; ED50 ; effective dose 50 ; Emax ; maximal effect ; ORX ; orchidectomized ; ADT ; androgen deprivation therapy
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：106-114
• 全文大小：1120 K
• 卷排序：167

文摘

Androgen-induced direct decrease in systemic blood pressure in rats with hypertension. Androgens play a significant role in the control of blood pressure and may contribute to the pathogenesis of hypertension. A blockade of L-VOCC may be involved in the antihypertensive effects of androgens. Testosterone deprivation by orchidectomy may be a factor responsible for the development of hypertension, and testosterone replacement therapy may prevent these increases in blood pressure.