Blocking metabotropic glutamate receptor subtype 5 relieves maladaptive chronic stress consequences

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• 作者：Daniel Peterlik^a ; Christina Stangl^a ; Amelie Bauer^a ; Anna Bludau^a ; Jana Keller^a ; Dominik Grabski^a ; Tobias Killian^a ; Dominic Schmidt^b ; Franziska Zajicek^a ; Georg Jaeschke^d ; Lothar Lindemann^c ; Stefan O. Reber^e ; Peter J. Flor^a ; ^{peter.flor@ur.de} ; Nicole Uschold-Schmidt^a ; ^{nicole.uschold@ur.de}
• 关键词：mGlu5 ; Knockout ; CTEP ; Chronic subordinate colony housing ; Chronic psychosocial stress ; Stress-protective phenotype
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：79-92
• 全文大小：1787 K
• 卷排序：59

文摘

The role of mGlu5 in modulating consequences of chronic psychosocial stress using the CSC paradigm was investigated. Genetic ablation and pharmacological blockade of mGlu5 decreased the vulnerability to CSC-induced alterations. CSC exposure dysregulated hippocampal mGlu5 binding sites in wildtype mice. mGlu5 seems to be involved in chronic psychosocial stress-induced affective and somatic consequences.