FoxP2 directly regulates the reelin receptor VLDLR developmentally and by singing
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- 作者：Iris Adam ; iris.adam@fu-berlin.de" class="auth_mail" title="E-mail the corresponding author ; Ezequiel Mendoza emendoza@zedat.fu-berlin.de" class="auth_mail" title="E-mail the corresponding author ; Ursula Kobalz kobalz@zedat.fu-berlin.de" class="auth_mail" title="E-mail the corresponding author ; Sandra Wohlgemuth sandra.wohlgemuth@fu-berlin.de" class="auth_mail" title="E-mail the corresponding author ; Constance Scharff ; constance.scharff@fu-berlin.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Birdsong ; Synaptic transmission ; FoxP2 ; VLDLR ; Gene regulation
- 刊名：Molecular and Cellular Neuroscience
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：96-105
- 全文大小：1717 K
文摘
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VLDLR established as the first direct target gene of FoxP2 in vivo in songbirds
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FoxP2 knockdown affects AMPA/NMDA ratio and VLDLR transcription in medium spiny neurons of the avian song nucleus Area X.
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FoxP2 binds to the avian VLDLR promoter.
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VLDLR expression depends on FoxP2 expression in contexts that require neural plasticity.
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Establishes VLDLR as a candidate linking FoxP2 to structural and functional spine plasticity in avian medium spiny neurons