Smart composite materials based on chitosan microspheres embedded in thermosensitive hydrogel for controlled delivery of drugs
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- 作者：Marieta Constantin ; Sanda-Maria Bucatariu ; Florica Doroftei ; Gheorghe Fundueanu ; ghefun@icmpp.ro
- 关键词：Smart composite hydrogel ; Thermoresponsive polymer ; Chitosan ; Microsphere ; Drug release
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：10 February 2017
- 年：2017
- 卷：157
- 期：Complete
- 页码：493-502
- 全文大小：3133 K
- 卷排序：157
文摘
A pH/temperature-responsive composite hydrogel was designed and developed. The sharpness of phase transition largely depended to the cross-linking degree. The release rate of drug strongly depended to the pH and temperature. The thermo-responsive network had a weak protection against microspheres degradation.