Syndrome de?dyshormon¡§|mie euthyro?dienne au?cours de?la?maladie aigu? grave

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• 作者：Vicente Miguel Bayarri¹ ; ^{miguel_vic@gva.es} ; Susana Sancho¹ ; Carmen Campos¹ ; Rafael Faus¹ ; Jose M. Simó ; n¹ ; Elena Porcar¹ ; Constantino Tormo¹ ; Antonio Hernandez²
• 刊名：La Presse M¡§|dicale
• 出版年：2007
• 出版时间：November 2007
• 年：2007
• 卷：36
• 期：11_part_P1
• 页码：1550-1556
• 全文大小：326 K

文摘

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Summary

Objective

To describe euthyroid sick syndrome (ESS) and its different clinical variants in severe acute illness.

Design

This prospective cohort study examined hormone results and outcome for patients admitted to our intensive care unit (ICU).

Methods

In this heterogeneous group of 108 patients from our ICU we analyzed the prevalence of ESS and its influence on mortality and sought to determine if any thyroid indicators had a prognostic value.

Results

The prevalence of ESS was similar to that described by other authors (68.5 % for ESS type I, 15.7 % for type II and 1.9 % for type III). Patients developed thyroid alterations on their third day of hospitalization and those with ESS type II had a higher mortality rate. The only thyroid indicator with prognostic value was a reverse triiodothyronine (rT3) value exceeding 0.61 ng/mL.

Conclusion

Severe acute illness induced the thyroid alterations known as ESS. Type I had the highest prevalence, but type II was correlated with a higher mortality rate. The only thyroid indicator with a prognostic value was rT3.