5α,8α-Epidioxysterols from the gorgonian Eunicella cavolini

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• 作者：Efstathia Ioannou ; Ayman F. Abdel-Razik ; Maria Zervou ; Dimitrios Christofidis ; Xanthippi Alexi ; Constantinos Vagias ; Michael N. Alexis ; Vassilios Roussis
• 关键词：Eunicella cavolini ; Trididemnum inarmatum ; 5α ; 8α ; -Epidioxysterols ; Structure elucidation ; Antiproliferative activity
• 刊名：Steroids
• 出版年：2009
• 出版时间：January 2009
• 年：2009
• 卷：74
• 期：1
• 页码：73-80
• 全文大小：350 K

文摘

Three new (1, 4, 9) and nine previously reported (2, 3, 5–8, 10–12) 5α,8α-epidioxysterols were isolated from the organic extracts of the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum. The structures and relative configurations of 1–12 were established on the basis of detailed NMR spectroscopic analyses and comparison with the literature. The growth inhibitory effects of 1–12 were evaluated against MCF-7 human breast cancer cells. Compound 1, bearing a cyclopropyl moiety in the side chain, exhibited the highest antiproliferative activity.