TNF alpha signaling is associated with therapeutic responsiveness to vascular disrupting agents in endocrine tumors
详细信息 查看全文
- 作者：Constanze Hantela ; Constanze.Hantel@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Alexandra Ozimekb ; Regia Lirac ; Bruno Ragazzond ; Carsten Jä ; ckele ; Roman Frantseva ; Martin Reinckea ; Jé ; rô ; me Bertheratd ; Thomas Mussackb ; Felix Beuschleina
- 关键词：Endocrine tumors ; Tumor-Vascular-Disrupting-Agent ; TNFα ; TNFAIP3/A20
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：5 March 2016
- 年：2016
- 卷：423
- 期：Complete
- 页码：87-95
- 全文大小：869 K
文摘
- •
We compare two models for endocrine tumors with different therapeutic responsiveness.
- •
We identified TNFAIP3/A20 as overexpressed in the therapy-resistant tumor model.
- •
We reveal a correlation between TNFAIP3 expression and survival in human ACC samples.