Constitutive NF-κB activation in AML: Causes and treatment strategies
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- 作者：Matthieu Cornelis Johannes Bosman ; Jan Jacob Schuringa ; Edo Vellenga ; e.vellenga@umcg.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：AML ; NF-κB ; Survival ; Apoptosis
- 刊名：Critical Reviews in Oncology and Hematology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：98
- 期：Complete
- 页码：35-44
- 全文大小：1568 K
文摘
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NF-κB activity can be enhanced by chromosomal translocations or mutations driving AML.
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The expression of various components within the NF-κB pathway is increased in AML.
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High proteasome activity might result in constitutive NF-κB activity in AML.
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Novel compounds targeting the constitutive NF-κB activity are described.