Sex differences in hypothalamic-mediated tonic norepinephrine release for thermal hyperalgesia in rats
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- 作者：M. Wagnera ; T. Banerjeea ; Y. Jeongb ; &dagger ; ; yjeong2@khu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; J.E. Holdena ; jeholden@umich.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CCI ; chronic constriction injury ; CoCl ; cobalt chloride ; DβH ; dopamine β-hydroxylase ; GEE ; generalized estimating equation ; ir ; immunoreactive ; LH ; lateral hypothalamus ; NE ; norepinephrine ; PWL ; paw withdrawal latency ; SNRI ; serotonin norepinephrine reuptake inhibitor ; TH ; tyrosine-hydroxylase
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：2 June 2016
- 年：2016
- 卷：324
- 期：Complete
- 页码：420-429
- 全文大小：606 K
文摘
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Tonic release of norepinephrine was pronociceptive at α1-adrenoceptors.
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Antinociception from α2-adrenoceptors was not observed.
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No sex difference was seen after blockade of A7 catecholamine cell group.
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Sex differences occurred in hypothalamic-mediated tonic norepinephrine release.