CCI-induced postoperative mechanical allodynia and thermal hyperalgesia.
Up-regulation of CXCL5 and CXCR2 expression and GSK-3β activity in spinal dorsal horn after CCI treatment.
Intrathecal blockage of CXCL5/CXCR2 effectively ameliorated CCI-induced neuropathic pain.
CXCL5/CXCR2 inhibition down-regulated spinal GSK-3β activity in CCI-induced neuropathic pain.
Intrathecal delivery of CXCL5 induced pain hypersensitivity, which was attenuated by GSK-3β inhibitor.