Genetic markers of long-term treatment outcome could improve the prognosis of bipolar disorder.
Single SNPs and molecular pathways were analyzed in a genome-wide association study.
TRAF3IP2-AS1, RNLS, DFNB31, NFYC and DEPTOR genes were predictors of total episode rate.
The DFNB31 gene was strongly associated with the risk of depressive recurrence.
Top pathways mediate the regulation of MAPK cascade and learning/memory processes.