ZYZ451 protects cardiomyocytes from hypoxia-induced apoptosis via enhancing MnSOD and STAT3 interaction
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- 作者：Shanshan Luoa ; x_shan_shan@163.com" class="auth_mail" title="E-mail the corresponding author ; Xianfeng Gub ; xfgu@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Fenfen Maa ; cdc343cdc001@163.com" class="auth_mail" title="E-mail the corresponding author ; Chunhua Liuc ; liuchunhua@nankai.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yaqi Shena ; shenyaqi1982@163.com" class="auth_mail" title="E-mail the corresponding author ; Ruowen Ged ; dbsgerw@nus.edu.sg" class="auth_mail" title="E-mail the corresponding author ; Yizhun Zhua ; e ; zhuyz@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：HPLC ; high performance liquid chromatography ; MnSOD ; Manganese-containing superoxide dismutase ; STAT3 ; signal transducer and activator of transcription 3 ; CAT ; catalase ; CoIP ; co-immunoprecipitation ; GPx ; glutathione peroxidase ; GSH ; glutathione ; GSSG ; oxidized glutathione ; LDH ; lactate dehydrogenase ; MDA ; malondialchehyche ; mitoROS ; mitochondrial reactive oxidative species ; NAC ; N-acetyl cysteine ; NRVCs ; neonatal rats ventricular cardiomyocytes ; post-MI ; post-myocardial infarction ; SPRC ; S-prop
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：1-14
- 全文大小：4545 K
文摘
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Mitochondrial STAT3 participates in reducing mitoROS production in hypoxia.
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STAT3 interacts with MnSOD.
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ZYZ451 increases MnSOD activity by enhancing the interaction between MnSOD and STAT3.