A highly efficient stereocontrolled synthesis of (S

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• 作者：Daniele Balducci ; Simone Contaldi ; Ilaria Lazzari ; Gianni Porzi
• 刊名：Tetrahedron: Asymmetry
• 出版年：2009
• 出版时间：2 July 2009
• 年：2009
• 卷：20
• 期：12
• 页码：1398-1401
• 全文大小：320 K

文摘

A new, practical and very convenient stereocontrolled synthesis of (S)-2′,6′-dimethyltyrosine [(S)-Dmt] 4 was accomplished in a good yield, starting from the chiral synthon 1,4-N,N-[(S)-phenylethyl]-piperazine-2,5-dione 1. The procedure, which is an extension of our original strategy and occurs with a high level of stereoselectivity (>98 % ), is simple and inexpensive allowing us to prepare the unnatural α-aminoacid (S)-Dmt also on a multi-gram scale.