- 作者：Maria-Angela Losi ; MD ; FESC?/sup> ; Sandro Betocchi ; MD ; FESC?/sup> ; sandro.betocchi@unina.it ; Marcello Chinali ; MD&dagger ; ; Giovanni Barbati ; MD?/sup> ; Gianluigi D’ ; Alessandro ; MD?/sup> ; Alessandra Cacace ; MD?/sup> ; Raffaella Lombardi ; MD?/sup> ; Carla Contaldi ; MD?/sup> ; Giovanni de Simone ; MD ; FACC ; FAHA&dagger ; ; Massimo Chiariello ; MD ; FACC ; FESC?/sup>
- 刊名：Journal of the American Society of Echocardiography
- 出版年：2007
- 出版时间：November 2007
- 年：2007
- 卷：20
- 期：11
- 页码：1253-1259
- 全文大小：508 K
Background
This study was conceived to assess associations between integrated backscatter signal at end diastole (IBS) and diastolic properties in patients with hypertrophic cardiomyopathy.Methods
In 46 patients with hypertrophic cardiomyopathy, septal IBS was calculated by both applying an appropriate regression correction (IBSc) and by relating it to pericardial reflectivity (IBSp). Difference in duration between transmitral forward and pulmonary venous backward velocities (A-Ar) was measured as an estimate of passive diastolic filling. In all, 38 patients underwent ambulatory electrocardiogram monitoring for 48 hours.
Results
IBS inversely correlated to both A-Ar (IBSc, r = ?522, P < .001; IBSp, r = ?302, P = .041) and mitral peak velocity at atrial contraction (IBSc, r = ?464, P = .002; IBSp, r = ?413, P = .004). Moreover, IBS was greater in patients with sustained or nonsustained ventricular tachycardia (IBSc, 28.5 ¡À 3.8 vs 25.4 ¡À 3.8 dB, P = .034).
Conclusions
Septal IBS correlates with Doppler parameters of left ventricular chamber stiffness in patients with hypertrophic cardiomyopathy. Increased IBS is associated with presence of ventricular arrhythmias.