Xenotransplantation of cryopreserved ovarian tissue from patients with ovarian tumors into SCID mice—no evidence of malignant cell contamination
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- 作者：Laura Lotz ; Markus Montag ; Hans van der Ven ; Michael von Wolff ; Andreas Mueller ; Inge Hoffmann ; David Wachter ; Matthias W. Beckmann ; Ralf Dittrich
- 关键词：Fertility preservation ; ovarian tissue cryopreservation ; ovarian cancer ; xenotransplantation ; malignant contamination
- 刊名：Fertility and Sterility
- 出版年：2011
- 出版时间：30 June 2011
- 年：2011
- 卷：95
- 期：8
- 页码：2612-2614.e1
- 全文大小：660 K
文摘
This study examined the possible presence of malignant cells in ovarian cortex from patients with ovarian tumors after xenografting of the ovarian tissue into severe combined immunodeficiency mice. None of the mice presented symptoms of reintroduced malignancy nor did microscopic and immunohistochemical evaluation of the grafts raise any suspicion of residual malignant disease.