Preventive effect of Gardenia jasminoides on HCl/ethanol induced gastric injury in mice

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• 作者：Shaocheng Chen^a ; ^b ; ^c ; ¹ ; Xin Zhao^a ; ^b ; ^c ; ¹ ; Peng Sun^a ; ^b ; ^c ; Jun Qian^d ; Yanhong Shi^d ; ^e ; ^{yhs_lucky@163.com} ; Rui Wang^d ; ^{wangelle@hotmail.com}
• 关键词：Lactobacillus casei Qian ; Geniposide ; Ethanol ; Gastric injury ; Expression
• 刊名：Journal of Pharmacological Sciences
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：133
• 期：1
• 页码：1-8
• 全文大小：1719 K
• 卷排序：133

文摘

The therapeutic effect on HCl/ethanol induced gastric injury of Gardenia jasminoides (JXGJ-1 and JXGJ-2) were determined by a animal model. JXGJ-2 group reduced area of its gastric injury as compared to the control group, JXGJ-2 also helped in decreasing the gastric secretion volume results raised in pH value. The NO contents in serum, heart, liver, kidney and stomach of JXGJ-2 group were more than JXGJ-1 and control groups. JXGJ-2 reduce cytokine levels as compared to JXGJ-1 and control group. The serum and gastric tissue SOD, GSH-Px, GSH levels in JXGJ-2 treated mice were higher than JXGJ-1 treated and control mice, but the MDA, PC levels showed the crosscurrents, these levels were close to normal mice. Gardenia jasminoides could increase the occludin, EGF, EGFR, VEGF, IκB-α, nNOS, eNOS, Cu/Zn-SOD, Mn-SOD, CAT, GSH-Px (GSH1) mRNA and protein expressions and decrease the p38MAPK (p38), NF-κB, Bcl-2, COX-2, iNOS expressions in gastric tissues unlike to the control mice, JXGJ-2 had much better effect than JXGJ-1. JXGJ-1contained the higher genipin gentiobioside and gardenoside, they might be the key components of gastric injury inhibition. Gardenia jasminoides had a remarkable effect on gastric injury, and they were derived from two important components of genipin gentiobioside and gardenoside.