The role of α-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling
详细信息 查看全文
- 作者：Arti V. Shinde ; Claudio Humeres ; Nikolaos G. Frangogiannis ; nikolaos.frangogiannis@einstein.yu.edu
- 关键词：Myofibroblast ; α-Smooth muscle actin ; Myocardial infarction ; Extracellular matrix ; Transforming growth factor-β
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：1863
- 期：1
- 页码：298-309
- 全文大小：1977 K
- 卷排序：1863
文摘
In healing infarcts, scar contraction is associated with accumulation of α-SMA-expressing myofibroblasts. Culture of cardiac myofibroblasts in collagen pads causes disassembly of stress fibers, and reduces α-SMA and collagen synthesis. Serum and bFGF increase contraction of fibroblast-populated collagen pads, despite attenuating α-SMA synthesis. α-SMA knockdown attenuates serum-induced contraction of fibroblast-populated collagen pads. α-SMA overexpression also reduces pad contraction, attenuating fibroblast proliferative activity.