Evaluation of Acute Kidney Injury Using Contrast Ultrasonography in a Rabbit Model of Crush Syndrome

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• 作者：Chundong Zhang^&lowast ; ; ^{ultrasoundzc@163.com} ; Xin Wang^&dagger ; ; Jie Tang^&Dagger ;
• 关键词：Acute kidney injury ; Area under the curve ; Rabbits ; Crush syndrome
• 刊名：Ultrasound in Medicine & Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：2
• 页码：494-499
• 全文大小：1687 K
• 卷排序：43

文摘

This study aimed to investigate the feasibility of evaluating acute kidney injury (AKI) using contrast ultrasonography in a rabbit model of crush syndrome. Sixty-four New Zealand white rabbits were anesthetized and the left hind limb was wrapped and compressed for 4 h with a sphygmomanometer. Contrast ultrasonography of the left kidney using microbubbles as the contrast medium was performed. The serum levels of blood urea nitrogen (BUN), creatine (Cr), creatine kinase (CK) and lactate dehydrogenase (LDH) were significantly increased in comparison to before the compression. Correlation analysis showed that peak intensity was negatively correlated with the biochemical parameters and area under the curve (AUC) was positively correlated with these parameters. Contrast ultrasonography is thus sensitive to the changes in renal perfusion after limb crush injury in rabbits. The ultrasonography results correlated well with the biochemical parameters that are related to muscle injury and AKI.