Role of NADPH oxidases in inducing a selective increase of oxidant stress and cyclin D1 and checkpoint 1 over-expression during progression to human gastric adenocarcinoma
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- 作者：Eduardo E. Montalvo-Javé ; a ; d ; Marisela Olguí ; n-Martí ; nezb ; Diego R. Herná ; ndez-Espinosac ; Lourdes Sá ; nchez-Sevillab ; Edgar Mendieta-Condadob ; Martha L. Contreras-Zentellab ; Luis F. Oñ ; ate-Ocañ ; ae ; Tomá ; s Escalante-Tatersfieldd ; Agustí ; n Echegaray-Donded ; Juan M. Ruiz-Molinae ; Miguel F. Herreraf ; Julio Morá ; nc ; Rolando Herná ; ndez-Muñ ; ozb ; rhernand@ifc.unam.mx" class="auth_mail" title="E-mail the corresponding author
- 关键词：NOX1 ; Apoptosis ; Antioxidant defences ; Glutathione ; NAD/NADH ratio
- 刊名：European Journal of Cancer
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：57
- 期：Complete
- 页码：50-57
- 全文大小：1459 K
文摘
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Reactive oxygen species (ROS) may play a role in gastric carcinogenesis.
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We found two different patterns of oxidant status for tumour-free gastric mucosa and adenocarcinoma.
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Human gastric adenocarcinoma occurs with selectively increased lipid peroxidation.
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Adenocarcinoma's over-expression of NADPH oxidase 1 is related with cell proliferation and apoptosis.
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Altogether results in ‘low tone’ ROS formation and reduced cytoplasmic redox potential.