Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity

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• 作者：Donovan A. Argueta^a ; Nicholas V. DiPatrizio^a ; ^b ; ^c ; ^{ndipatri@ucr.edu}
• 关键词：Endocannabinoid ; 2-AG ; Anandamide ; Peripheral ; Western diet ; Obesity
• 刊名：Physiology & Behavior
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：171
• 期：Complete
• 页码：32-39
• 全文大小：889 K
• 卷排序：171

文摘

Mice maintained on a western diet become obese and display hyperphagia. Hyperphagia results from increases in meal size and rate of consumption. Intestinal and plasma endocannabinoids increase in western diet-induced obese mice. Inhibiting peripheral endocannabinoid signaling normalizes feeding patterns.