Convection-enhanced delivery of MANF 鈥?Volume of distribution analysis in porcine putamen and substantia nigra
详细信息 查看全文
- 作者：N.U. Baruaa ; A.S. Bienemanna ; M. Woolleyb ; M.J. Wyatta ; D. Johnsonb ; O. Lewisb ; C. Irvingb ; G. Pritchardb ; S. Gilla ; annub@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Convection-enhanced delivery ; Mesencephalic astrocyte-derived neurotrophic factor ; Parkinson's Disease
- 刊名：Journal of the Neurological Sciences
- 出版年：2015
- 出版时间：15 October 2015
- 年：2015
- 卷：357
- 期：1-2
- 页码：264-269
- 全文大小：1301 K
文摘
- •
Convection-enhanced delivery of MANF in porcine putamen and substantia nigra results in widespread distribution.
- •
MANF distribution correlates well with co-infused gadolinium-DTPA visualised with real-time MRI.
- •
This study confirms the translational potential of CED of MANF as a novel treatment strategy for Parkinson's Disease.