Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin
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- 作者：Takayuki Hattoria ; Miho Watanabe-Takahashib ; Nobumichi Ohokaa ; Takashi Hamabatac ; Koichi Furukawad ; Kiyotaka Nishikawab ; Mikihiko Naitoa ; miki-naito@nihs.go.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Stx ; Shiga toxin ; STEC ; Shiga toxin-producing Escherichia coli ; ER ; endoplasmic reticulum ; FLIP ; FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein ; c-IAP1 ; cellular inhibitor of apoptosis protein 1 ; Mcl-1 ; myeloid cell leukemia 1 ; PARP ; Poly(ADP-ribose) polymerase ; PI ; propidium iodide ; BRZ ; bortezomib ; CHX ; cycloheximide
- 刊名：FEBS Open Bio
- 出版年：2015
- 出版时间：2015
- 年：2015
- 卷：5
- 期：Complete
- 页码：605-614
- 全文大小：2003 K
文摘
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Shiga toxin (Stx) rapidly reduces the level of short-lived anti-apoptotic proteins.
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Stx induces activation of caspase 9 and apoptosis.
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Proteasome inhibitors prevent the reduction of anti-apoptotic proteins.
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Proteasome inhibitors suppress Stx-induced apoptosis.
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Bortezomib prolongs the survival of mice challenged with a lethal dose of Stx.