Inhibition of Fas death signals by FLIPs

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• 作者：Tschopp ; Jü ; rg ; Irmler ; Martin ; Thome ; Margot
• 关键词：c^&minus ; cellular ; CrmA cytokine response modifier A ; DD death domain ; DED death-effector domain ; FADD Fas-associated DD ; FasL Fas ligand ; FLICE Fas-associated death-domain-like IL-1β ; -converting enzyme ; FLIP FLICE-inhibitory protein ; IAP i
• 刊名：Current Opinion in Immunology
• 出版年：1998
• 出版时间：October, 1998
• 年：1998
• 卷：10
• 期：5
• 页码：552-558
• 全文大小：609 K

文摘

The death receptor Fas is a member of the tumor necrosis factor receptor family; upon interaction with its ligand it efficiently activates caspases and induces apoptosis. Despite abundant Fas surface expression, however, Fas death-signals are frequently interrupted. Many viruses express antiapoptotic proteins, including caspase inhibitors, Bcl-2 homologues and death-effector-domain-containing proteins that are termed FLIPs (FLICE [Fas-associated death-domain-like IL-1β-converting enzyme]-inhibitory proteins). Cellular homologues of these inhibitors have been identified. Cellular FLIPs structurally resemble caspase-8 except that they lack proteolytic activity. FLIPs are highly expressed in tumor cells, T lymphocytes and healthy, but not injured, myocytes; this suggests a critical role of FLIPs as endogenous modulators of apoptosis.