Synthesis and pharmacological activity of diorganoantimony(III) and triorganoantimony(V) derivatives of Schiff bases derived from amino acids

详细信息    查看全文

• 作者：Rita Gupta^a ; ^{ritagupta16@rediffmail.com} ; Manas Mathur^b ; Ajit Kumar Swami^b ; Jyoti Sharma^a ; Yashpal Singh^a
• 关键词：Diorganoantimony(III) ; Triorganoantimony(V) ; Bifunctional bidentate ; Antioxidant ; Antimicrobial ; Antiplatelet
• 刊名：Journal of Saudi Chemical Society
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：21
• 期：1
• 页码：67-75
• 全文大小：1047 K
• 卷排序：21

文摘

Some new diorganoantimony(III) and triorganoantimony(V) compounds of Schiff bases derived from amino acids having the general formula Ph2Sb[OC(R)CHC(R′)NC(Y) COOH] [where R = CH3, R′ = C6H5, Y = H2CH2(1), −HCH2C6H5(2); R = R′ = C6H5, Y = H2CH2(3), HCH2C6H5(4)] have been synthesized by the reaction of Ph3Sb with RC (O) CHC(R′) NHC(Y) COOH in 1:1 M ratio. Whereas Ph3Sb[OC(R)CHC(R′)NC(Y) COOH]2 (where R = CH3, R′ = C6H5, Y = H2CH2(5), R = R′ = C6H5, Y = HCH2C6H5(6)) have been synthesized by the reactions of Ph3SbBr2 with Na [OC(R) CHC(R′)NC(Y) COOH] in 1:2 M ratio, respectively in anhydrous benzene. All these compounds have been characterized by elemental analyses and molecular weight measurement. Probable structures of these compounds have been proposed on the basis of spectral studies (I.R. 1H and 13C NMR). Schiff base (R = CH3 R′ = C6H5, Y = H2CH2) and its corresponding organoantimony(III) and -antimony(V) compounds have been screened for antimicrobial, antioxidant and antiplatelet activities. These synthesized compounds can be used as new class of antimicrobial, antioxidant and antiplatelet agents with potential for clinical development.