Selenium, copper and iron in veterinary medicine—From clinical implications to scientific models

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• 作者：Esther Humann-Ziehank ^{esther.humann-ziehank@tiho-hannover.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Trace elements ; Animal models ; Farm animals ; Interdisciplinary studies
• 刊名：Journal of Trace Elements in Medicine and Biology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：37
• 期：Complete
• 页码：96-103
• 全文大小：1388 K

文摘

Diseases related to copper, selenium or iron overload or deficiency are common and well-described in large animal veterinary medicine. Some of them certainly have the potential to serve as useful animal models for ongoing research in the field of trace elements. Obvious advantages of large animal models compared to laboratory animal models like rats and mice are the option of long-term, consecutive examinations of progressive deficient or toxic stages and the opportunity to collect various, high volume samples for repeated measurements. Nevertheless, close cooperation between scientific disciplines is necessary as scientists using high sophisticated analytical methods and equipment are not regularly in touch with scientists working with large animal diseases. This review will give an introduction into some typical animal diseases related to trace elements and will present approaches where the animal diseases were used already as a model for interdisciplinary research.