Integrative characterization of the venom of the coral snake Micrurus dumerilii (Elapidae) from Colombia: Proteome, toxicity, and cross-neutralization by antivenom
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- 作者：Paola Rey-Suá ; reza ; ofidpa@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Vitelbina Nú ; ñ ; eza ; b ; Juliá ; n Ferná ; ndezc ; Bruno Lomontec
- 关键词：Micrurus dumerilii ; Coral snake ; Venom ; Elapid toxins ; Proteomics ; Venomics
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：16 March 2016
- 年：2016
- 卷：136
- 期：Complete
- 页码：262-273
- 全文大小：1160 K
文摘
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The venom proteome of Micrurus dumerilii from Colombia was determined.
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Phospholipases A2 are the predominant proteins, among 11 families.
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The venom induces a conspicuous myotoxic effect, reproduced by some PLA2s.
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Two PLA2s and a three-finger toxin reproduce the lethal venom effect.
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Anti-Micrurus nigrocinctus antivenom cross-neutralizes M. dumerilii venom.