Stiff-Leg syndrome is a rare autoimmune central nervous system disorder.
Specific therapy exists for patients with SLS and anti-GAD65 antibodies such as intravenous Ig.
We recommend to search for Anti GAD ab in case of stiff legged gait with negative work-up.
Diagnosing isolated leg conditions such as SLS or dystonia might be challenging.
“Stiff HemiSyndrome” might be considered as a junction of SLS and SPS.