Biophysical characterization and antineoplastic activity of new bis(thiosemicarbazonato) Cu(II) complexes

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• 作者：Elisa Palma^a ; ^b ; Filipa Mendes^a ; Goreti Ribeiro Morais^a ; ¹ ; Inê ; s Rodrigues^a ; Isabel Cordeiro Santos^a ; Maria Paula C. Campello^a ; Paula Raposinho^a ; Isabel Correia^b ; Sofia Gama^a ; ² ; Dulce Belo^a ; Ví ; tor Alves^c ; Antero J. Abrunhosa^c ; Isabel Santos^a ; Antó ; nio Paulo^a ; ^{apaulo@ctn.tecnico.ulisboa.pt}
• 关键词：Copper ; Bis(thiosemicarbazones) ; Metallodrugs ; Cancer theranostics
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：68-79
• 全文大小：1098 K
• 卷排序：167

文摘

New Cu(II) bis(thiosemicarbazonate) complexes with pendant protonable cyclic amines Biological Evaluation studies: cytotoxic activity, cell uptake, and protein/DNA binding The new Cu(II)complexes are able to circumvent cisplatin cross-resistance. Remarkably augmented cellular uptake as proved by studies performed with 64Cu complexes