- 作者：Gustavo Falbo Wandalsena ; gfwandalsen@uol.com.br" class="auth_mail" title="E-mail the corresponding author ; gfwandalsen@unifesp.br" class="auth_mail" title="E-mail the corresponding author ; Fernanda de Cordoba Lanzaa ; b ; Má ; rcia Cristina Pires Nogueiraa ; Dirceu Solé ; a
- 关键词：Chloral hydrate ; Hypnotics and sedatives ; Infant
- 刊名：Revista Paulista de Pediatria (English Edition)
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：34
- 期：4
- 页码：408-411
- 全文大小：402 K
Methods
All sedation attempts for pulmonary function tests in infants carried out between June 2007 and August 2014 were evaluated. Obstructive sleep apnea and heart disease were contraindications to the exams. Anthropometric data, exam indication, used dose, outcomes of sedation and clinical events were recorded and described.
Results
The sedation attempts in 277 infants (165 boys) with a median age of 51.5 weeks of life (14–182 weeks) were evaluated. The main indication for the tests was recurrent wheezing (56%) and the chloral hydrate dose ranged from 50 to 80mg/kg (orally). Eighteen (6.5%) infants had some type of clinical complication, with the most frequent being cough and/or airway secretion (1.8%); respiratory distress (1.4%) and vomiting (1.1%). A preterm infant had bradycardia for approximately 15 minutes, which was responsive to tactile stimulation. All observed adverse effects were transient and there was no need for resuscitation or use of injectable medications.
Conclusions
The data demonstrated that chloral hydrate at the employed doses is a safe and effective medicament for sedation during short procedures in infants, such as pulmonary function tests. Because of the possibility of severe adverse events, recommendations on doses and contraindications should be strictly followed and infants should be monitored by trained staff.