Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
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- 作者：Omkar U. Kawalekar1 ; Roddy S. O&rsquo ; Connor2 ; Joseph A. Fraietta1 ; Lili Guo3 ; Shannon E. McGettigan1 ; Avery D. Posey Jr.1 ; Prachi R. Patel1 ; Sonia Guedan1 ; John Scholler1 ; Brian Keith1 ; Nathaniel Snyder3 ; 4 ; Ian Blair3 ; Michael C. Milone1 ; 2 ; 5 ; Carl H. June1 ; 2 ; 5 ; cjune@exchange.upenn.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：16 February 2016
- 年：2016
- 卷：44
- 期：2
- 页码：380-390
- 全文大小：2420 K
文摘
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CAR T cells containing 4-1BB signaling domains have enhanced in vitro persistence
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Increased central memory differentiation of CD8+ CAR T cells expressing 4-1BB
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CD28-enforced metabolic reprograming enhances glycolytic metabolism
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Mitochondrial biogenesis is selectively induced in 4-1BB CAR T cells